UFC 321 Aspinall vs Gane Predictions, Odds & Betting Tips

UFC Heavyweight Champion Tom Aspinhall is set to defend his title against Ciryl Gane at UFC 321 on Saturday, October 25, 2025. The fight will take place inside the Etihad Arena in Abu Dhabi, and there’s a tasty undercard.

We’ll bring you our expert predictions for the fight, as well as the current odds and some betting tips. The defending champion is the strong favorite for this fight, so we’re going to have to look at alternative markets to bet on this bout. Winning methods and rounds betting look like the best way to go for this one.

Our #1 pick for betting this month

UFC 321: Aspinhall vs Gane – The key facts

This Saturday, Tom Aspinall is defending his UFC Heavyweight Title for the first time as the undisputed champion. He became the interim Heavyweight Champion back in November 2023 and has since been promoted following Jon Jones’ retirement.

To begin with, here are the key facts about this event:

Aspinhall vs Gane: UFC fight predictions

Before we give you our UFC sports betting predictions for this one, here’s a quick look at the two fighters and their chances:

Tom Aspinhall – The strong favorite to retain the title

This might be Tom Aspinall’s first defence as the undisputed UFC Heavyweight Champion. However, he’s held the interim title since November 2023, when he knocked out Sergei Pavlovich in 1 minute 9 seconds at UFC 295.

He has since defended his interim title once at UFC 305 in a highly anticipated rematch against Curtis Blaydes. Unsurprisingly, he goes into this fight as a strong favorite at 1.27 odds.

Cyril Gane – A strong contender

UFC 321 will be a long-awaited second shot at the UFC heavyweight title for Gane. He was defeated by the now-returned former champion by submission in March 2023.

Since then, Gane has won his last two fights, following his TKO defeat of Serghei Spivac with a narrow decision win against Alexander Volkov. He’s a strong contender with a Maui Thai fighting style, but it looks like a second title loss looms for the 3.95 longshot underdog.

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UFC 321: Aspinhall vs Gane odds and betting tips

We’re almost certain that Aspinhall will win this fight, but at 1.27 odds with most UFC betting sites, a straight win bet is hardly worth a punt. Given Aspinhall’s penchant for knock-out punch wins (his last three fights have ended this way), a KO/TKO bet looks like the way to go.

However, the price for this is still a bit too short at 1.91 odds. To add value, we need to look at the round in which Aspinhall will knock out Gane.

All three of Aspinhall’s recent KO punch wins have happened in the first round. While Gane is a slightly more formidable opponent, we still fancy the British fighter to repeat his recent results.

On most of our top-rated online bookies, you can get an Aspinhall Round 1 win by KO as a combo bet for odds in and around the 4.72 mark. This, for us, looks like the best way to bet on this fight.

Betting tips and odds summary

• Aspinhall win odds: 1.27
• Gane win odds: 3.95
• Betting tip: Aspinhall Round 1 win by KO
• Best odds for our top tip: 4.72

UFC 321 undercard

Before we go, here’s a quick look at the undercard:

UFC 321: Aspinhall vs Gane betting predictions – Conclusion

Whether you fancy backing our top tip for the main event or you’re looking at betting the undercard, you can find the top MMA sportsbooks right here. Simply check the list and click one of the promo banners on this page to claim your betting welcome bonus in time for UFC 321: Aspinall vs Gane.

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