NFL Week 3 Predictions & Odds – 2025 Picks & Betting Tips
The 2025 National Football League season continues, and we’re covering the NFL odds for week 3. There are intriguing matchups featuring divisional rivalries for fans and pundits’ pleasure. This schedule runs from this Thursday, September 18, till Monday, September 22.
Week 3 starts with the Dolphins vs the Bills on Thursday night. This is followed by a series of 14 games, including Chiefs vs Giants, Titans vs Colts, and 49ers vs Cardinals. The game week ends with Lions vs Ravens on Monday night. Below, we provide expert opinions on key fixtures and tips to get the most value for your entertainment.
Our #1 pick for betting this month
Week 3 NFL schedule
Two weeks into the National Football League (NFL) season, and we’ve witnessed some incredible fixtures. Week 3, which runs from 18-22 September, features several primetime games.
Interestingly, leading NFL betting sites give fans ways to engage with this week’s action. They offer popular betting markets, including spreads, totals, and Home/Away wins at various intervals (halves and quarters) for each game.
Here’s a preview of NFL games to check out this week:
Thursday night football: Buffalo Bills vs Miami Dolphins
The third round begins with an AFC (American Football Conference) East Clash. The Miami Dolphins are visiting the Buffalo Bills on Thursday, September 18. Buffalo has won their first two games this season and dominated this rivalry, winning 13 of the last 14 meetings. The visitors, however, have lost their first two matches and are looking to bounce back.
Expert pundits are giving the Bills a roughly 80% chance to win outright. Many sportsbooks have the hosts’ odds at -833 and the visitors’ at +573.
Sunday football: More rivalries await
There are 14 Sunday games, with the earliest fixtures starting at 1 pm EST (Eastern Standard Time) and the last one beginning at 8:20 pm EST. Each matchup showcases divisional battles and surprises that can keep fans on the edge of their seats. Here are a few key games that may catch your attention.
Tennessee Titans vs Indianapolis Colts
This AFC South matchup kicks off the early Sunday games. Titans (+146) host the Indianapolis Colts (-172) and are aiming for their third win of the season. Many experts place the visitors as underdogs, given the fact that Indy has a commanding lead in this series with a 39-22 record.
However, the Colts have beaten the Titans over the last two seasons, winning four games in a row. So, fans can expect surprises and drama this Sunday.
San Francisco 49ers vs Arizona Cardinals
This is a crucial NFC (National Football Conference) matchup between two undefeated teams this season. These rivals play each other fiercely, and fans can anticipate intense energy on the pitch.
However, with the home advantage and a head-to-head record of 36-31 in the host’s favor, we expect the 49ers (-125) to win.
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New York Giants vs Kansas City Chiefs
This is the only game scheduled for Sunday night, and it has a surprising twist. The Chiefs (-263) are winless in their last two games for the first time since 2014, but they remain clear favorites against the hosts. Despite a shaky start to the 2025/26 season, the team’s offense still commands respect, and visiting fans are optimistic about a win at MetLife Stadium.
The Giants (+216), also winless in their first two games for the third consecutive year, are looking to bounce back after their Week 2 defeat to the Dallas Cowboys (40-37) in overtime.
Notably, this rivalry favors the home team, winning 11 of its 15 matchups against the Chiefs. The Giants have also led by at least 10 points in the last four meetings. However, scoring has been low in those games, with total points falling below 45. Therefore, we anticipate this game to end with a total score under 45.5 (-120).
Monday night football: Baltimore Ravens vs Detroit Lions
Week 3 ends with one of the most anticipated games: the Detroit Lions (+216) visit the Baltimore Ravens (-263) at MetLife Stadium. Both teams, after their opening week defeats, have recorded strong victories in Week 2.
The host’s offense has been intriguing, scoring 40+ in both games, though they lost to Buffalo in Week 1 (40-41). Also, the visitors rebounded from a poor Week 1 to score 52 points in their last match against the Chicago Bears.
History favors the hosts, as they dominated Detroit 38-6 in their last encounter and hold a 6-1 win record in their seven meetings. Given that both teams scored over 40 points in Week 2, we also expect a total of over 51.5 (-117) on Monday night.
Betting tips to note in NFL Week 3
The NFL odds for Week 3 are live, and it’s crucial to make strategic plays so you can stay entertained from Thursday to Monday. Here are a few tips to note:
Since it’s a new season, it’s too early to evaluate a team’s form. For example, the Kansas Chiefs’ winless start to the season may surprise fans. But their talent level still makes them favorites against the Giants on Sunday night.
Early lines vary between sportsbooks and can fluctuate. Getting in early may secure better spreads, totals, and moneyline odds.
Once the games start, odds can change fast with every play. As such, it’s important to use the best betting apps that let you make last-minute adjustments on the go. These apps combine real-time updates and live betting features for your convenience.
Don’t miss the NFL Week 3 action
Week 3 of the 2025 football season offers a mix of storylines. Can the Chiefs bounce back from their winless streak, or will the Bills’ dominance over the Dolphins continue? The answers will reveal themselves on Thursday night and end in a thrilling Monday night football.
Before then, you can use the insights provided in this article to make informed picks and get set to enjoy the games ahead. If you don’t have a trusted betting site yet, you can choose one of our recommended sportsbooks from our banners.